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You should use ledger-live if you want to also be able to access your account with ledger live.
You can use „legacy / MEW“ if you don’t use ledger live to access the account. That’s what i use, personally.
The BIP44 derivation path is in fact only used by Trezor, but the first account will be the same at the Ledger Live first account. I would recommend using it only if you use a trezor, since it is not supported by other Ethereum front-ends.
The bip39 passphrase that you mention (that you incorrectly call 25th word) is completely unrelated to the derivation path you use. So you can pick either derivation path, whether you use a bip39 passphrase or not.