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> They’re supported through 3rd party hot wallets.
Ensure you follow the manual’s (trezor.io/learn) advice on how to pair these. They should be paired cold, not HOT. To make them hot would be to share the seed-mnemonic which is discouraged.
> Metamask. How safe is to connect my Trezor to Metamask? I know not to insert the Trezor generated seed in the hot wallet. What else should I be aware of? TIA
Since they are paired cold, the 3rd party wallet can’t do anything but ask the Trezor to sign stuff. So long as you decode and understand what it signs, and approve it’s contents, then there is no risk, even running a fake metamask. Just enter, validate, check your seed-mnemonic. These are all attempts to learn your secrets.