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For connecting your Ledger device to MetaMask on desktop, it’s important to note that there are known issues with Firefox due to U2F compatibility problems. Try using Chrome or Brave instead of Edge or Firefox because both browsers support WebHID. You’ll also want to ensure both MetaMask and Chrome/brave are updated to the latest versions.
Regarding mobile use, the Ledger Nano S Plus does not support Bluetooth connectivity, which is required for mobile connections to MetaMask. This means you can only use the Nano S Plus with a desktop via a USB connection.
Finally, for Ledger Live mobile issues, you’ll want to ensure that everything, including your Ledger Live app, device firmware, and device apps, is up to date. You can perform a complete update of your Ledger setup by following the guide [here](https://support.ledger.com/hc/en-us/articles/8458939792669-How-to-perform-a-complete-update-of-your-Ledger-setup?docs=true). If the steps mentioned do not resolve the issue, you can open a support ticket on our site [here](https://support.ledger.com/) for more in-depth help.